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KMID : 0895820140240030039
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Journal of Oriental Rehabilitation Medicine
2014 Volume.24 No. 3 p.39 ~ p.50
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Protective Effects of Banggi-eum (FangchiYin) on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats
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Jung Hae-Chang
Jeong Su-Hyeon
Seo Il-Bok
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Abstract
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Objectives : The objective of this study is to investigate the protective effects of Banggi-eum (FangchiYin) on the articular cartilage injuries in rat model of osteoarthritis.
Methods : Articular cartilage injury was induced by injection of monosodium iodoacetate (MIA) (0.25 mg) into both knee joint cavities of rats. Rats were divided into control group (n=8) and Banggi-eum (FangchiYin) group (n=8), which was taken extracts of Banggi-eum (FangchiYin) by orally for 20 days. At the end of the experiment (20 days after MIA injection), gross and histopathological examinations on the articular structures of knee joints were performed. Proteoglycan (PG) content in articular cartilages was analyzed by safranin O staining method. And also, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) contents in synovial fluid were measured by ELISA method.
Results : 1. Grossly, the degree of articular cartilage injury in the Banggi-eum (FangchiYin) group was alleviated compared with the control group. 2. PG content in articular cartilage of the Banggi-eum (FangchiYin) group was increased significantly compared with the control group. 3. Histopathologically, osteoarthritic score of the Banggi-eum (FangchiYin) group was decreased significantly compared with the control group. 4. TNF-α and IL-1β content in synovial fluid of the Banggi-eum (FangchiYin) group was increased compared with the control group. But there was no significance.
Conclusions : On the basis of these results, we suggest that Banggi-eum (FangchiYin) have inhibiting effects on the progression of articular cartilage injury in MIA-induced osteoarthritis model.
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KEYWORD
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Banggi-eum, FangchiYin, Monosodium iodoacetate, Articular cartilage injury, Proteoglycan
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